Hampton Siliconized Glass Cover Slides

Hampton Siliconized Glass Cover Slides

ApplicationsHanging, sitting or sandwich drop crystallization
FeaturesHigh purity of glassSiliconized, hydrophobic glass surface0.22 mm & 0.96 mm glass thicknessThicker glass slides preserve temperature longer12 mm, 18 mm, & 22 mm glass diameterCircle & squareUV Compatible (>85% transmission)
12 x 0.22 mm Circle
18 x 0.22 mm Circle
22 x 0.22 mm Circle & Square
Description
Siliconized glass cover slides allow a droplet to be suspended in a position which provides near optimal conditions for vapor diffusion with the surrounding reservoir solution. These siliconized glass cover slides provide a consistent, high quality finish for crystallization experiments. The hydrophobic surface produces a drop which “stands well” and does not flatten on the glass. The siliconized surface prevents the adhesion of crystals and precipitate onto the glass surface. Use Dow Corning Vacuum Grease (HR3-510), Dow Corning 7 Release Compound (HR3-508), or immersion oil to seal cover slide to plate. Available in 12, 18 or 22 mm diameter circles and 22 mm diameter squares. Available in 0.22 mm or 0.96 mm glass thickness. The 0.96 mm thick slides are virtually unbreakable during crystallization handling.
The following slides are UV transmissable (>85%):
HR3-277 and HR3-279 – 12 mm x 0.22 mm Siliconized circle cover slides
HR3-231 and HR3-233 – 22 mm x 0.22 mm Siliconized circle cover slides
HR3-239 and HR3-241 – 18 mm x 0.22 mm Siliconized circle cover slides
HR3-215 and HR3-217 – 22 mm x 0.22 mm Siliconized square cover slides

图片

图片
Plain Glass Cover Slides
ApplicationsHanging, sitting or sandwich drop crystallization
Features
0.22 mm glass thickness
12 mm glass diameter
Hydrophilic glass surface
Circle & squareDescription
Plain, non-siliconized, hydrophilic glass cover slides. Useful for hanging drop, sitting drop, and sandwich drop vapor diffusion crystallization methods. The hydrophilic surface creates a drop which is more flat than a drop on a siliconized surface. This offers enhanced imaging for very small drops. Use Dow Corning® Vacuum Grease (HR3-510), Dow Corning® 7 Release Compound (HR3-508), or immersion oil to seal cover slide to plate.
HR3-209T 12 mm Plain circle cover slides for Tecan robot 5 oz case (~2,400 slides)
图片

图片
HR3-209T 12 mm Plain circle cover slides for Tecan robot 5 oz case (~2,400 slides)
PEN-VAC Kit
ApplicationsHolding and manipulating small, flat surfaces such as glass cover slides
FeaturesSelf-contained vacuumNo power neededCompactDescription
PEN-VAC is a great tool for handling small, flat surfaced objects such as plain and siliconized cover slides, as well as plastic slides. Simply depress the side button, touch the tip to the object to be lifted and release the button. PEN-VAC creates a totally self-contained vacuum that lifts up to 50 grams for up to one minute. Less than an ounce, the lightweight aluminum body fits in a pocket. No power supply needed. The kit includes one PEN-VAC with 5 3/4″ blue body, (3) angled and (3) straight probes with (2) each 1/8”, 1/4”, 3/8” diameter blue silicone vacuum cups . It is packaged in a clear plastic storage case.
图片
HR3-251  PEN-VAC Kit

wako抗体

wako抗体

货号 名称 规格
011-15801 ANTI ZAP-70 RABBIT 200UL
308-08791 ANTI VITELLOGENIN MONOCLONAL ANTIBODY (5A4) 100UG
334-00011 ANTI VIP, RABBIT 50UL
017-19781 ANTI VGLUT-2,RABBIT 50UG
010-19771 ANTI VGLUT-1, RABBIT 50UG
630-06961 ANTI VDR MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLONE NO. 100UL
012-16431 ANTI V-ATPASE A SUBUNIT, RABBIT 100UG
300-08991 ANTI VANILLOID RECEPTOR SUBTYPE 1(VR-1) (CAPSAICIN RECEP 5UG
307-09001 ANTI VANILLOID RECEPTOR LIKE PROTEIN 1(VRL-1) ANTIBODY 5UG
334-00251 ANTI UROTENSIN 2 (HUMAN) ANTISERUM 50UL
309-15551 ANTI URATE TRANSPORTER 1 (URAT1) POLYCLONAL ANTIBODY 25UG
011-17481 ANTI TRYPTASE, MONOCLONAL ANTIBODY 100UL
309-06641 ANTI TROPONIN-T, MONOCLONAL ANTIBODY 1MG
306-06651 ANTI TROPONIN-T, MONOCLONAL ANTIBODY 1MG
632-06921 ANTI TRBETA1 MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLONE 100UL
303-06661 ANTI TRANSFERRIN, MONOCLONAL ANTIBODY 1MG
308-05131 ANTI TRANSFERRIN 100UG
638-06901 ANTI TRALPHA MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLONE 100UL
019-17781 ANTI TRAIL/APO2L, RABBIT 500UG
636-06941 ANTI TR2 MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLONE NO. 100UL
019-11321 ANTI TORPEDO ACETYLCHOLINE RECEPTOR, RABBIT,AFF.PUR.IGG 1MG
638-06881 ANTI TLX MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLONE NO. 100UL
010-11851 ANTI THYMOCYTE(RABBIT), LYOPHILIZED 1ML
017-18701 ANTI THIOREDOXIN, MONOCLONAL ANTIBODY 200UG
308-13821 ANTI TESSP4 POLYCLONAL ANTIBODY 100UL
301-13811 ANTI TESSP4 POLYCLONAL ANTIBODY 100UL
011-15781 ANTI SYNTAXIN, MONOCLONAL ANTIBODY 100UG
018-15791 ANTI SYNAPTOBREVIN 2,RABBIT 100UG
013-15621 ANTI SYK (101) 200UG
338-00391 ANTI SPAI-1 ANTISERUM 50UL
019-17801 ANTI SOLUBLE GUANYLATE CYCLASE(SGC), MAB CLON#MAB3221 20UG
017-18201 ANTI SOLUBLE GUANYLATE CYCLASE MONOCLONAL ANTIBODY NO 214 20UG
014-15771 ANTI SNAP-25 MONOCLONAL ANTIBODY 100UG
012-15211 ANTI SIAYL LEWIS X(SLEX), MONOCLONAL ANTIBODY 218 100UL
012-15191 ANTI SIALYL LEWIS A(ALEA), MONOCLONAL ANTIBODY 218 1ML
304-14521 ANTI SIAH2 POLTCLONAL ANTIBODY, RABBIT 25UG
307-14511 ANTI SIAH1 POLTCLONAL ANTIBODY, RABBIT 25UG
634-06861 ANTI SALL1 MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLONE NO 100UL
301-08801 ANTI S19 RIBOSOMAL PROTEIN, POLYCLONAL ANTIBODY 100UG
306-14601 ANTI S14G-HUMANIN POLYCLONAL ANTIBODY, RABBIT 25UG
630-06841 ANTI RXRGAMMA MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLONE 100UL
636-06821 ANTI RXRBETA MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLONE 100UL
632-06801 ANTI RXRALPHA MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLONE 100UL
014-16251 ANTI RP105 RAT, MONOCLONAL ANTIBODY 200UG
632-06781 ANTI RORGAMMA MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLONE 100UL
638-06761 ANTI RORALPHA MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLONE 100UL
634-06741 ANTI ROR COMMON MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLO 100UL
630-06721 ANTI REVERBBETA MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLO 100UL
636-06701 ANTI REVERBALPHA MOUSE MONOCLONAL ANTIBODY (1MG/ML, CL 100UL
301-09901 ANTI RELATED TO B0, +TYPE AMINO ACID TRANSPORTER (BAT1) 25UG
307-05101 ANTI RAT ALBUMIN 100UG
301-09881 ANTI RAT 4F2 HEAVY CAHIN(4F2HC) POLYCLONAL ANTIBODY, RABBIT 25UG
636-06681 ANTI RARGAMMA MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLONE 100UL
632-06661 ANTI RARBETA MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLONE 100UL
638-06641 ANTI RARALPHA MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLONE 100UL
013-18921 ANTI RANK RECEPTOR, SOLUBLE, RABBIT 50UG
017-18441 ANTI RANK LIGAND SOLUBLE, RABBIT 500UG
304-13041 ANTI RAGE(RECEPTOR FOR AGE) POLYCLONAL ANTIBODY, RABBI 100UG
305-08821 ANTI PYRRALINE, MONOCLONAL ANTIBODY (H12) 20UG
334-00371 ANTI PYR33 -PANCREASTATIN (PORCINE, 33-49) ANTISERUM 50UL
334-00371 ANTI PYR33 -PANCREASTATIN (PORCINE, 33-49) ANTISERUM 50UL
307-05081 ANTI PROLACTIN 100UG
013-17321 ANTI PRESENILIN-1 (N-TERMINUS), GOAT 1MG
634-06621 ANTI PR ISOFORM B MOUSE MONOCLONAL ANTIBODY (1MG/ML, C 100UL
630-06601 ANTI PR COMMON MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLON 100UL
636-06561 ANTI PPARGAMMA2 MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLO 100UL
638-06521 ANTI PPARGAMMA COMMON MOUSE MONOCLONAL ANTIBODY (1MG/M 100UL
632-06541 ANTI PPARGAMMA COMMON MOUSE MONOCLONAL ANTIBODY 100UL
630-06581 ANTI PPARDELTA MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLON 100UL
634-06501 ANTI PPARALPHA MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLON 100UL
019-16441 ANTI PORCINE H+/K+-ATPASE ALPHA SUBUNIT, RABBIT 100UL
339-00061 ANTI PORCINE BIG ENDOTHELIN-1 (22-39), RABBIT 50UL
306-14461 ANTI POEM/NEPHRONECTIN POLYCLONAL ANTIBODY, RABBIT 50UG
309-14711 ANTI PODOCALYXIN, POLYCLONAL ANTIBODY, RABBIT 25UG
634-06481 ANTI PNR MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLONE NO. 100UL
012-16171 ANTI PI3 KINASE (P85 ALPHA SUBUNIT), MONOCLONAL ANTIB 1ML
307-15971 ANTI PHOTOTROPIN 1 POLYCLONAL ANTIBODY 25UG
011-16261 ANTI PHOSPHTYROSIN MONOCLONAL ANTIBODY (OY20) 100UG
016-14371 ANTI PHOSPHOTYROSINE, MONOCLONAL ANTIBODY 218 100UG
014-20281 ANTI PHOSPHORYLATED ALPHA-SYNUCLEIN,MONOCLONAL ANTIBODY 50UL
301-15991 ANTI PHOSPHOLIPID SCRAMBLASE 2 POLYCLONAL ANTIBODY 100UG
302-14061 ANTI PERIOD3 POLYCLONAL ANTIBODY, RABBIT 200UG
306-14081 ANTI PERIOD2 POLYCLONAL ANTIBODY, RABBIT 200UG
305-14051 ANTI PERIOD2 POLYCLONAL ANTIBODY, RABBIT 200UG
309-14071 ANTI PERIOD2 POLYCLONAL ANTIBODY, RABBIT 200UG
308-14041 ANTI PERIOD2 POLYCLONAL ANTIBODY, RABBIT 200UG
012-17151 ANTI PERFORIN, RAT MONOCLONAL ANTIBODY 100UG
015-16301 ANTI PERFORIN MONOCLONAL ANTIBODY 100UG
306-10201 ANTI PEDF MONOCLONAL ANTIBODY(14K) 50UG
305-14551 ANTI PDX1 POLYCLONAL ANTIBODY, RABBIT 25UG
016-16831 ANTI PARP, MONOCLONAL ANTIBODY, AFFINITY PURIFIED 100UG
019-16821 ANTI PARP C-TERMINUS,RABBIT 100UL
014-17471 ANTI P73ALPHA, RABBIT 50UG
336-00451 ANTI OSTEOCALCIN (HUMAN, 38-49) ANTISERUM 50UL
305-14791 ANTI ORGANIC CATION TRANSPORTER 3, POLYCLONAL ANTIBODY 25UG
302-09931 ANTI ORGANIC ANION TRANSPORTER 4 (OAT4) POLYCLONAL ANYIB 20UG
306-09951 ANTI ORGANIC ANION TRANSPORTER 3 (OAT3) POLYCLONAL ANYIB 25UG
305-09921 ANTI ORGANIC ANION TRANSPORTER 3 (OAT3) POLYCLONAL ANY 25UG
309-09941 ANTI ORGANIC ANION TRANSPORTER 2 (OAT2) POLYCLONAL ANYIB 25UG
308-09911 ANTI ORGANIC ANION TRANSPORTER 2 (OAT2) POLYCLONAL ANY 25UG
305-13211 ANTI ORGANIC ANION TRANSPORTER 1 (OAT1) POLYCLONAL ANY 25UG
339-00441 ANTI OREXIN-A (HUMAN) ANTISERUM 50UL
338-00031 ANTI NPY, RABBIT 50UL
019-18641 ANTI NNOS, MAB CLON NO.C7 214 1ML
303-10191 ANTI NITROTYROSINE MONOCLONAL ANTIBODY(2H1) 100UG
344-90661 ANTI NITROGUANOSINE POLYCLONAL ANTIBODY 10UG
348-90681 ANTI NITROGUANOSINE POLYCLONAL ANTIBODY 50UG
347-90651 ANTI NITROGUANOSINE MONOCLONAL ANTIBODY (CLONE NO2G52) 10UG
341-90671 ANTI NITROGUANOSINE MONOCLONA ANTIBODY (CLONE NO2G52) 50UG
630-06461 ANTI NGFI-BGAMMA MOUSE MONOCLONAL ANTIBODY (1MG/ML, CL 100UL
636-06441 ANTI NGFI-BALPHA MOUSE MONOCLONAL ANTIBODY (1MG/ML, CL 100UL
016-15731 ANTI NGF MONOCLONAL ANTIBODY 200UG
010-11471 ANTI NEUROTENSIN,RABBIT 100UL
308-06611 ANTI MYOGLOBIN, MONOCLONAL ANTIBODY 1MG
305-15411 ANTI MUPHAGE GP44 POLYCLONAL ANTIBODY, RABBIT 25UG
304-08771 ANTI MUMMICHOG VITELLOGENIN MONOCLONAL ANTIBODY (3E11) 100UG
302-06751 ANTI MULTI-UBIQUITIN CHAIN, MONOCLONAL ANTIBODY (CLONE:FK2) 1MG
305-06741 ANTI MULTI-UBIQUITIN CHAIN, MONOCLONAL ANTIBODY (CLONE:FK1) 1MG
300-14741 ANTI MUCOSA ASSOCIATED LYMPHOID TISSUE 1, POLYCLONAL A 25UG
303-13871 ANTI MT3-MMP POLYCLONAL ANTIBODY 100UL
306-13861 ANTI MT2-MMP POLYCLONAL ANTIBODY 100UL
309-13851 ANTI MT2-MMP POLYCLONAL ANTIBODY 100UL
632-06421 ANTI MR MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLONE NO. H 100UL
306-15441 ANTI MOK PROTEIN KINASE POLYCLONAL ANTIBODY, RABBIT 25UG
301-13791 ANTI MMP-23 (HMIFR) POLYCLONAL ANTIBODY 100UL
304-13781 ANTI MMP-23 (HMIFR) MONOCLONAL ANTIBODY 50UL
304-13801 ANTI MKLK2 (GK24) POLYCLONAL ANTIBODY 100UL
307-13651 ANTI MILK OSTEOPONTIN, MONOCLONAL ANTIBODY 50UG
332-00431 ANTI MIDKINE (HUMAN, 1-59) ANTISERUM 50UL
308-08811 ANTI METALLOTHIONAIN, MONOCLONAL ANTIBODY (CLONE NO. 1A12) 100UG
309-14451 ANTI MEF POLYCLONAL ANTIBODY, RABBIT 10UG
300-15461 ANTI MDC1 (NFBD1/KIAA0170) POLYCLONAL ANTIBODY, RABBIT 25UG
302-15421 ANTI MATRIX GLA PROTEIN POLYCLONAL ANTIBODY, RABBIT 50UG
303-08981 ANTI MACROPHAGE/MONOCYTE MONOCLONAL ANTIBODY (CLONE N 50UG
306-08971 ANTI MACROPHAGE/DENDRITIC CELLS MONOCLONAL ANTIBODY(CLON 50UG
309-08961 ANTI MACROPHAGE SURFACE ANTIGEN MONOCLONAL ANTIBODY (C 50UG
304-09751 ANTI MACROPHAGE SCAVENGER RECEPTOR (CD204) MONOCLONAL 50UG
331-00261 ANTI LYSENIN ANTISERUM 50UL
638-06401 ANTI LXRBETA MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLONE 100UL
638-06381 ANTI LXRALPHA RIGAND BINDING DOMAIN MOUSE MONOCLONAL A 100UL
634-06361 ANTI LXRALPHA MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLONE 100UL
019-14481 ANTI LUTENIZING HORMONE, MONOCLONAL ANTIBODY 1MG
307-09861 ANTI L-TYPE AMINO ACID TRANSPORTER 1(LAT1) POLYCLONAL 25UG
307-09741 ANTI L-TYPE AMINO ACID TRANSPORTER 1 (LAT1) MONOCLONAL 20UG
636-06321 ANTI LRH-1 MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLONE NO 100UL
630-06341 ANTI LRH-1 MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLONE NO 100UL
016-16571 ANTI LEX, MONOCLONAL ANTIBODY 1ML
016-11451 ANTI LEUCINE-ENKEPHALIN, FROM RABBIT 100UL
019-17041 ANTI LEPTIN,RABBIT 500UG
301-08781 ANTI KILLIFISH VITELLOGENIN MONOCLONAL ANTIBODY (3C1) 100UG
304-15981 ANTI KF-1 POLYCLONAL ANTIBODY 25UG
301-05121 ANTI INTERLEUKIN-8 100UG
011-15301 ANTI INTERLEUKIN 5, RABBIT 0.5MG
018-15311 ANTI INTERLEUKIN 5, MONOCLONAL ANTIBODY NO. D138 0.5MG
301-06601 ANTI INSULIN, MONOCLONAL ANTIBODY 1MG
012-18631 ANTI INOS, MAB CLON NO. A2 1ML
015-18621 ANTI INOS PEPTIDE, RABBIT 500UL
308-15381 ANTI INITIATE FACTOR 5 POLYCLONA ANTIBODY, RABBIT 25UG
308-14781 ANTI INITIATE FACTOR 3, POLYCLONAL ANTIBODY, RABBIT 25UG
017-16001 ANTI INDUCIBLE 100UL
014-17351 ANTI IL-5 RECEPTOR MONOCLONAL ANTIBODY (T-21) 100UG
017-17341 ANTI IL-5 RECEPTOR MONOCLONAL ANTIBODY (H-7) 100UG
637-00413 ANTI IGE, RAT MONOCLONAL ANTIBODY 200UL
307-06201 ANTI HUMAN ALBUMIN, RABBIT, WHOLE ANTISERUM 10ML
309-51233 ANTI HUMAN ALBUMIN, RABBIT, IGG WHOLE 5ML
304-06211 ANTI HUMAN ALBUMIN, RABBIT, IGG WHOLE 5ML
303-51231 ANTI HUMAN ALBUMIN, RABBIT, IGG WHOLE 1ML
301-06221 ANTI HUMAN ALBUMIN, RABBIT, AFFINITY PURIFIED 1ML
300-06551 ANTI HUMAN ALBUMIN, MONOCLONAL ANTIBODY 1MG
300-06171 ANTI HUMAN ALBUMIN, GOAT, WHOLE ANTISERUM 10ML
307-06181 ANTI HUMAN ALBUMIN, GOAT, IGG WHOLE 5ML
304-06191 ANTI HUMAN ALBUMIN, GOAT, AFFINITY PURIFIED 1ML
016-17051 ANTI HSP90 ALPHA, MONOCLONAL ANTIBODY 200UG
018-17251 ANTI HSP27, MONOCLONAL ANTIBODY 5ML
013-17061 ANTI HS90BETA,MONOCLONAL ANTIBODY 200UG
632-06301 ANTI HNF4ALPHA7 MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLO 100UL
638-06261 ANTI HNF4ALPHA MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLON 100UL
632-06281 ANTI HNF4ALPHA MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLON 100UL
301-15511 ANTI HMGB3 POLYCLONAL ANTIBODY, RABBIT 25UG
303-06801 ANTI HEPATITIS B SURFACE(HBS), MONOCLONAL ANTIBODY 1MG
309-06261 ANTI HEMOGLOBIN, SHEEP, IGG WHOLE 5ML
302-06251 ANTI HEMOGLOBIN, RABBIT, WHOLE ANTISERUM 10ML
307-51251 ANTI HEMOGLOBIN, RABBIT, IGG WHOLE 1ML
307-06561 ANTI HEMOGLOBIN, MONOCLONAL ANTIBODY (CLONE:SU-110) 1MG
304-06571 ANTI HEMOGLOBIN, MONOCLONAL ANTIBODY (CLONE:SU-104) 1MG
308-06231 ANTI HEMOGLOBIN, GOAT, WHOLE ANTISERUM 10ML
305-06241 ANTI HEMOGLOBIN, GOAT, IGG WHOLE 5ML
304-05091 ANTI HEMOGLOBIN 100UG
302-06631 ANTI HAPTOGLOBIN, MONOCLONAL ANTIBODY 1MG
014-16991 ANTI H. PYLORI HSP60, MONOCLONAL ANTIBODY 200UG
335-00041 ANTI GRP RABBIT 50UL
337-00361 ANTI GRF (HUMAN) ANTISERUM 50UL
018-20463 ANTI GREEN FLUORESCENT PROTEIN, MONOCLONAL ANTIBODY (ANTI GF 5X100UL
012-20461 ANTI GREEN FLUORESCENT PROTEIN, MONOCLONAL ANTIBODY (ANTI GF 100UL
012-16551 ANTI GRANZYME B, MONOCLONAL ANTIBODY 100UG
634-06241 ANTI GR COMMON MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLON 100UL
015-16421 ANTI GLUTAMATE TRANSPORTER, RABBIT 200UG
016-17291 ANTI GLUTAMATE TRANSPORTER (GLAST), RABBIT 100UG
019-17281 ANTI GLUTAMATE TRANSPORTER (EAAC1), RABBIT 100UG
019-15581 ANTI GI3 (93-102), RABBIT 50UL
012-15571 ANTI GI2A (160-169), RABBIT 50UL
015-15561 ANTI GI1A (159-168) , RABBIT 50UL
304-14761 ANTI GHRELIN, POLYCLONAL ANTIBODY, RABBIT 25UG
302-13841 ANTI GELATINASE B POLYCLONAL ANTIBODY 100UL
305-13831 ANTI GELATINASE B POLYCLONAL ANTIBODY 100UL
015-15201 ANTI GASTRIC MUCIN M1G, MONOCLONAL ANTIBODY 1ML
308-10381 ANTI GALECTIN(GAL-3) POLYCLONAL ANTIBODY, RABBIT 100UG
330-00351 ANTI GALANIN (RAT) ANTISERUM 50UL
308-14541 ANTI G5PR POLYCLONAL ANTIBODY, RABBIT 25UG
630-06221 ANTI FXR MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLONE NO. 100UL
019-14501 ANTI FOLLICLE STIMULATING HORMONE 1MG
010-16091 ANTI FOLLICLE STIMULATING HORMONE 200UG
013-16081 ANTI FGF-9 MONOCLONAL ANTIBODY (13-3) 200UG
019-15341 ANTI FGF RECEPTOR MONOCLONAL ANTIBODY 1ML
300-05071 ANTI FERRITIN 100UG
019-16181 ANTI FAS, RABBIT 100UL
015-17261 ANTI FAS, RABBIT 100UL
013-16341 ANTI FAS, MAB(CLONE :SM1/1) 100UG
010-16351 ANTI FAS, MAB (CLONE : APO1-3) 100UG
012-17271 ANTI FAS LIGAND, RABBIT 100UL
636-06201 ANTI EZFIT MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLONE NO 100UL
636-06181 ANTI ERRGAMMA MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLONE 100UL
632-06161 ANTI ERRBETA MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLONE 100UL
638-06141 ANTI ERRALPHA MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLONE 100UL
634-06121 ANTI ERBETA MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLONE N 100UL
630-06101 ANTI ERALPHA MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLONE 100UL
300-13881 ANTI ENTEROPEPTIDASE POLYCLONAL ANTIBODY 100UL
010-15991 ANTI ENOS, RABBIT 100UL
332-00051 ANTI ENDOTHELIN-1 (1-21), RABBIT 50UL
335-00421 ANTI ELAFIN (HUMAN) ANTISERUM 50UL
303-14611 ANTI DYNEIN POLYCLONAL ANTIBODY, RABBIT 25UG
019-18521 ANTI DNASE R, MAB (CLONE : HG303) 100UG
014-19431 ANTI DNASE GAMMA, MONOCLONAL ANTIBODY (HG302) 100UG
309-06761 ANTI DINITROPHENOL, MONOCLONAL ANTIBODY 0.5MG
304-04991 ANTI DERFII, MONOCLONAL ANTIBODY (CLONE : 15E11) 100UG
308-05011 ANTI DERFII, MONOCLONAL ANTIBODY (CLONE : 13A4) PEROXIDASE C 50UG
307-04981 ANTI DERFII, MONOCLONAL ANTIBODY (CLONE : 13A4) 100UG
300-04971 ANTI DERFI, MONOCLONAL ANTIBODY (CLONE : 6G1) 100UG
301-05001 ANTI DERFI, MONOCLONAL ANTIBODY (CLONE : 2E1) PEROXIDASE CON 50UG
303-04961 ANTI DERFI, MONOCLONAL ANTIBODY (CLONE : 2E1) 100UG
308-06731 ANTI D-D DIMER, MONOCLONAL ANTIBODY 1MG
630-06081 ANTI DAX1 MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLONE NO. 100UL
017-13061 ANTI DAF,MONOCLONAL ANTIBODY FITC CONJUGATED 100UL
016-11951 ANTI DAF 100UL
305-15391 ANTI DAB1 POLYCLONAL ANTIBODY, RABBIT 25UG
541-00981 ANTI CYTOCHROME P450 3A4/5, MONOCLONAL ANTIBODY 50UL
544-00971 ANTI CYTOCHROME P450 2D6I, MONOCLONAL ANTIBODY 50UL
547-00961 ANTI CYTOCHROME P450 2D6, MONOCLONAL ANTIBODY 50UL
540-00951 ANTI CYTOCHROME P450 1A1, MONOCLONAL ANTIBODY 50UL
300-09851 ANTI CYSTINE/GLUTAMIC ACID TRANSPORTER(XCT) POLYCLONAL 25UG
010-14271 ANTI C-YES GENE PRODUCT,MONOCLONAL ANTIBODY(CLNO:3H9) 200UG
013-14261 ANTI C-YES GENE PRODUCT MONOCLONAL ANTIBODY CL#1B7 200UG
306-14721 ANTI CUBILIN, POLYCLONAL ANTIBODY, RABBIT 25UG
309-07861 ANTI CRYJ II, RABBIT, IGG FRACTION 100UG
302-07851 ANTI CRYJ I, RABBIT, IGG FRACTION 100UG
301-06461 ANTI CRP, SHEEP, WHOLE ANTISERUM 10ML
308-06471 ANTI CRP, SHEEP, IGG WHOLE 5ML
307-06441 ANTI CRP, RABBIT, WHOLE ANTISERUM 10ML
306-51221 ANTI CRP, RABBIT, IGG WHOLE 1ML
304-06451 ANTI CRP, RABBIT, IGG WHOLE 5ML
302-51223 ANTI CRP, RABBIT, IGG WHOLE 5ML
308-51281 ANTI CRP, MONOCLONAL ANTIBODY 1MG
304-51283 ANTI CRP, MONOCLONAL ANTIBODY 5MG
303-06421 ANTI CRP, GOAT, WHOLE ANTISERUM 10ML
300-06431 ANTI CRP, GOAT, IGG WHOLE 5ML
303-07881 ANTI CRJ II, POLYCLONAL ANTIBODY, PEROXIDASE CONJUGATE 25UG
305-07841 ANTI CRJ II, MONOCLONAL ANTIBODY (CLONE:T27) 100UG
306-07871 ANTI CRJ I, MONOCLONAL ANTIBODY (CLONE:053), PEROXIDASE CONJ 25UG
308-07831 ANTI CRJ I, MONOCLONAL ANTIBODY (CLONE:026) 100UG
301-07821 ANTI CRJ I, MONOCLONAL ANTIBODY (CLONE:013) 100UL
330-00091 ANTI CRF, RABBIT 50UL
014-18071 ANTI COX-2,RABBIT 100UL
012-18511 ANTI COX-1,MAB CLON# HPES01 500UG
015-18501 ANTI COX, RABBIT 100UL
636-06061 ANTI COUP-TF II MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLO 100UL
632-06041 ANTI COUP-TF I MOUSE MONOCLONAL ANTIBODY (1MG/ML, CLON 100UL
303-14591 ANTI COLD/MENTHOL RECEPTOR 1(TRPM8) POLYCLONAL ANTIBODY, RAB 25UG
333-00081 ANTI CNP-22 (1-22), RABBIT 50UL
304-09991 ANTI CML MONOCLONAL ANTIBODY (NF1G), PEROXIDAZE CONJUGATED 50UG
307-09981 ANTI CML MONOCLONAL ANTIBODY (NF1G), BIOTIN CONJUGATED 50UG
303-09961 ANTI CML MONOCLONAL ANTIBODY (NF1G) 50UG
302-08831 ANTI CML MONOCLONAL ANTIBODY (CLONE:CMS-10) 50UG
016-14251 ANTI C-LYN GENE PRODUCT, MONOCLONAL ANTIBODY 200UG
018-15051 ANTI C-LYN GENE PRODUCT CLONE LYN-8 214 200UG
331-00401 ANTI CINC-1/GRO (RAT) ANTISERUM 50UL
301-06721 ANTI CHORIONIC GONADOTROPIN(HCG), MONOCLONAL ANTIBODY 1MG
016-14491 ANTI CHORIONIC GONADOTROPIN B-C-TERMINAL PEPTIDE 218 1MG
308-14801 ANTI CHEMOKINE-LIKE FACTOR 1, POLYCLONAL ANTIBODY, RAB 25UG
333-00341 ANTI CGRP (HUMAN) ANTISERUM 50UL
019-14241 ANTI C-FYN CLONE FYN 301 200UG
012-14231 ANTI C-FGR GENE PRODUCT, MONOCLONAL ANTIBODY 214 200UG
302-10041 ANTI CEL MONOCLONAL ANTIBODY (KNH-30), PEROXIDASE CONJUGATED 50UG
305-10031 ANTI CEL MONOCLONAL ANTIBODY (KNH-30), BIOTIN CONJUGATED 50UG
300-09971 ANTI CEL MONOCLONAL ANTIBODY (KNH-30) 50UG
012-15951 ANTI CDK2, MONOCLONAL ANTIBODY 250UL
016-15351 ANTI CD44(GRANULOCYTES. T CELLS), MONOCLONAL ANTIBODY 500UG
016-16451 ANTI CD38, RAT MONOCLONAL ANTIBODY 200UG
301-09021 ANTI CD36 MONOCLONAL ANTIBODY (NF189) 50UG
336-00331 ANTI CCK-33 (PORCINE) ANTISERUM 50UL
303-14731 ANTI CATION-CHLORIDE-COTRANSPORTER 9, POLYCLONAL ANTIB 25UG
019-14981 ANTI CATHEPSIN E, RABBIT 1MG
015-14961 ANTI CATHEPSIN D, RABBIT 1MG
307-08761 ANTI CARP VITELLOGENIN MONOCLONAL ANTIBODY (IG2) 100UG
307-06681 ANTI CARCINO EMBRYONIC ANTIGEN(CEA), MONOCLONAL ANTIBO 1MG
304-06691 ANTI CARCINO EMBRYONIC ANTIGEN(CEA), MONOCLONAL ANTIBO 1MG
308-13441 ANTI CAM KINASE II DELTA1-DELTA4 POLYCLONAL ANTIBODY, RABBIT 200UG
309-15431 ANTI CALPAIN6 POLYCLONAL ANTIBODY, RABBIT 50UG
302-14441 ANTI CALNEXIN DELTA185-520 MONOCLONAL ANTIBODY (CLONE NO.2E9 50UG
339-00321 ANTI CALCITONIN (HUMAN) ANTISERUM 50UL
016-16191 ANTI CAK, RABBIT 250UL
010-15751 ANTI C5A RECEPTOR (CD88) 250UL
011-10161 ANTI C4,RABBIT 1ML
301-07061 ANTI BSP, MONOCLONAL ANTIBODY 50UG
303-15451 ANTI BRM POLYCLONAL ANTIBODY, RABBIT 25UG
013-15981 ANTI BRAIN NOS 100UL
013-16581 ANTI BOVINE SERUM ALBUMIN, CHICKEN 2MG
332-00311 ANTI BNP(1-26) ANTISERUM 50UL
015-17141 ANTI BNOS ANTIBODY SET 1SET
302-15541 ANTI BNAS2 POLYCLONAL ANTIBODY 25UG

anti-mettl3抗体[ epr18810 ](ab195352)

种属反应性

与反应:小鼠、大鼠、人预测可用于:绵羊、山羊、马、几内亚猪,牛,猫,狗,猪,非人类的灵长类动物anti-mettl3抗体[ epr18810 ](ab195352)
  • 应用 AB评论 说明 流式细胞 用于测定浓度依赖性。 免疫组化法 1 / 1000。 WB 1 / 1000。检测到的频带的约64 kDa(预测分子量:64 kDa)。

    牛奶推荐作为阻断剂。

    ihc-p 1 / 500。进行热三/ EDTA缓冲液pH 9开始前的免疫组化染色协议介导抗原修复。 国际商会/如果 1 / 1000。 IP 1 / 50。
  • 靶标

    数千种罕见肿瘤突变被鉴定,基于蛋白结构域鉴定致癌突变的新方法

    数千种罕见肿瘤突变被鉴定,基于蛋白结构域鉴定致癌突变的新方法

    当细胞中的遗传突变导致肿瘤的异常生长时,会出现癌症。一些癌症药物通过靶向针对一般形式的突变蛋白质(因为编码它们的基因发生突变)来攻击肿瘤细胞。然而,目前仅已确定了一小部分对癌症有显著促进作用的突变。

    日前,马里兰大学的托马斯·彼得森及其同事开发了一种新的统计分析方法,使用癌症患者的遗传数据来发现致癌突变。与以前关注个别基因突变的研究不同,新方法解决了相关蛋白家族共享的类似突变,可确定数以千计的之前被忽视的(尽管罕见)可能有助于癌症生长的遗传突变。这项研究发表在《 PLOS 计算生物学》杂志上,为研发新药铺平了道路。

    具体来说,新方法重点集中在被称为蛋白质结构域的蛋白质的亚组分中的突变上。即使不同的基因编码它们,不同的蛋白质可以共享共同的蛋白质结构域。该新策略利用蛋白质结构域和功能的现有知识来确定蛋白质结构域内位置更突出的肿瘤。

    使用这种新方法,研究人员确定了数千种罕见的肿瘤突变发生在与其他肿瘤的其他蛋白质中发现的突变相同的结构域位置——暗示着它们可能参与癌症的发生。

    Maricel Kann 研究的资深作者说:“也许只有两名患者在特定蛋白质中有突变,但是当你意识到这一区域与癌症患者其他蛋白质的突变位置完全相同时,你就意识到重要的是研究这两个突变。

    研究人员已经提出术语“oncodomain”是指更可能含有致癌突变的蛋白质结构域。 Oncodomains 的进一步研究可以帮助药物开发:“因为这么多蛋白质的结构域是相同的,”Kann 说,“单次治疗可能会解决广泛的突变型蛋白质引起的癌症。”

    参考文献:

    Oncodomains: A protein domain-centric framework for analyzing rare variants in tumor samples. https://doi.org/10.1371/journal.pcbi.1005428

    来源:来宝网

    该文章由WP-AutoPost插件自动采集发布

    原文地址:http://www.seq.cn/1250.html

    Active carbon‐dispersed silica gel 活性炭充填硅胶 019-11941 二恶英分析用

    Active carbon‐dispersed silica gel 活性炭充填硅胶 019-11941
    製品番号 01875-43
    和名 活性炭分散シリカゲル
    英名 Active carbon‐dispersed silica gel
    規格 ダイオキシン類分析用
    包装 10g
    価格 ¥10,000
    在庫 100≦
    製品情報
    活性炭充填硅胶 019-11941
    本产品仅用于研究用途。不得用于人体。
    用于二恶英分析中的预处理(净化)!
    [产品列表]
    019-11941
    ACTIVE CARBON-IMPREGNATED SILICAGEL
    活性炭预混硅胶
    10g
    1800.00
    活性炭充填硅胶是一种柱净化填料, 用于微量分析多氯二苯并对二恶英(PCDDs)和多氯二苯并呋喃(PCDFs)。微量分析要达到高精度要求,就少不了优异的样品净化方法。由于二恶英毒性特别高,引起社会广泛关注,因此进行二恶英分析时,安全性必须十分可靠。活性炭具有特异吸附具有平板结构的化合物的特性,譬如二恶英。活性炭净化在精制富集二恶英样品是必不可少的过程,这点得到全球广泛认可。然而,传统的活性炭颗粒存在这样的弱点:
    当颗粒较小时,渗透率较低,而颗粒较大时,在洗脱时会引起严重的拖尾现象。
    该新型色谱柱填料,采用活性炭充填入硅胶而成,不仅具有活性炭的优良特性,而且具备很好的渗透性。
    [质量标准]
    SPECIFICATION
    REQUIREMENT
    Appearance
    Blackish gray ~ black,
    granules ~ small granules
    Bulk density
    0.3~0.6g/ml
    Loss on drying at 105°C
    max.10.0%
    Suitability for dioxins determination (1)
    to pass test
    Suitability for dioxins determination (2)
    under investigation
    [操作程序]
    将玻璃棉放在色谱柱的底部,与一个旋塞相连接,加入高度约1厘米的无水硫酸钠。然后加入1g活性炭充填硅胶,轻轻晃动柱子以使厚度均匀。在顶部再次加入另一层的无水硫酸钠,高度约0.5厘米。(参考设备图。)
    当柱子装填完毕,马上用吸管将样品(需将正己烷溶液浓缩至0.3毫升左右)慢慢滴加到无水硫酸钠层上。然后用0.1毫升的正己烷数次洗涤管壁和无水硫酸钠层。
    静置几分钟后,在色谱柱上方连接一个装有200毫升25%[ v/v]的二氯甲烷/正己烷混合物的分液漏斗,轻轻让混合液缓缓流下来,开始以每秒钟1滴的速度进行洗脱。(该洗脱液不含二恶英。)
    当二氯甲烷/正己烷混合液加完,继续用200 mL甲苯以每秒1滴的流速进行洗脱。(该洗脱液含有二恶英。)
    将甲苯洗脱液用减压KD浓缩器浓缩至目标体积。
    [注意事项]
    多氯联苯可以用25%二氯甲烷/正己烷完全洗脱出来,用于定量分析。
    由于采用的是干燥型柱层析,在洗脱过程中,气泡会留在柱内。不过对于回收率和重现性无不良影响。
    当1,2,3,4-T4CDD 和O8CDD单组份荷载为1ng时,回收率超过90%。
    T4CDD : Tetrachlorodibenzo-p-dioxin 四氯二苯并-对-二恶英
    O8CDD : Octachlorodibenzo-p-dioxin 八氯二苯并-对-二恶英

    测序周报 · 科研篇:人类脐带血让衰老大脑“重返青春”

    人类脐带血让衰老大脑“重返青春”

    测序周报 · 科研篇:人类脐带血让衰老大脑“重返青春”

    根据斯坦福大学(Stanford University)医学院科学家的一项最新研究,人类脐带血可以恢复老年小鼠的学习和记忆能力。这其中的关键在于一种名为组织金属蛋白酶抑制剂-2(TIMP-2)的蛋白质,仅将TIMP-2注射到小鼠中便会取得相同的效果。这一成果发表于《自然》杂志上,可能催生出心理活动能力衰老的新疗法。

    “神经学家们一直以来忽略了一件重要的事情,那就是我们血液中的物质可能会影响到思维活动,”文章通讯作者Tony Wyss-Coray教授说道:“这让我感到很惊讶。”

    测序周报 · 科研篇:人类脐带血让衰老大脑“重返青春”

    ▲文章通讯作者Tony Wyss-Coray教授(图片来源:斯坦福大学官网)

    在之前的一项研究中,Tony Wyss-Coray教授的团队发现,直接将年轻小鼠的血浆输注至年老小鼠体内,会使后者受益。这些益处远远不只反映在一些生化和生理指标上,还包括在记忆和学习测试中的实际表现。

    在这项新的工作中,科学家们第一次证明了,人类血浆可以帮助老年小鼠改善记忆和学习能力,似乎在提示着在老年人体内也可能取得类似的有益效果。从药物开发的角度来看,这是一个十分有希望的成果,因为单个蛋白质便可在很大程度上实现上述效果。

    通过比较19-24岁、61-82岁人群的血浆和脐带血浆,科学家们发现了许多会随年龄增长而发生含量变化的血浆蛋白质。他们怀疑这些变化可能会影响大脑中的海马体,该部位在小鼠和人体中都对长时程记忆的产生至关重要,包括对空间信息和个人所经历事件的记忆。

    测序周报 · 科研篇:人类脐带血让衰老大脑“重返青春”

    ▲海马体在大脑中的位置(图片来源:medscape)

    由于某些未知的原因,海马体特别容易受到衰老过程的影响。随着年龄的增长,海马体会发生退化,出现萎缩和神经元减少,造成学习和记忆能力下降。此外,海马体的退化也是阿兹海默病的早期表现之一。

    科学家们选择了免疫缺陷型小鼠作为实验对象,因为这些小鼠不会对输入的人类血液发生免疫排斥反应。同时,这些免疫缺陷小鼠的海马体的衰老速度与正常小鼠相比,并无明显区别。科学家们将老年、年轻和“最年轻”(即脐带血)的人类血液输入上述小鼠,观察在这之后对海马体功能的影响,并通过Barnes迷宫测试的直接评估小鼠的学习和记忆能力。

    测序周报 · 科研篇:人类脐带血让衰老大脑“重返青春”

    ▲Barnes迷宫测试(图片来源:sylics)

    当在两周中每四天接受一次人类脐带血浆后,老年小鼠的海马体在许多功能指标上都出现了显着改善。相比之下,老年人的血浆则起不到上述效果,而年轻人的血浆则会起到较弱的改善效果。

    那么,脐带血中究竟有着怎样的神奇物质,会让衰老大脑变得年轻起来呢?

    科学家们发现,这一物质便是TIMP2蛋白。它在人类脐带血中含量丰富,也存在于出生后个体的血浆中,但会随着年龄的增长而含量逐渐降低。TIMP2属于TIMP蛋白家族,该家族共有四种蛋白,具有抑制可降解细胞外基质的多种金属蛋白酶的能力。TIMP2被发现可增强大脑神经元的活性。

    测序周报 · 科研篇:人类脐带血让衰老大脑“重返青春”

    ▲小鼠为育幼所筑的巢(图片来源:plexx.eu)

    若仅将TIMP2蛋白注射入老年小鼠体内,则可基本上复制脐带血浆带来的有益效果,甚至恢复了这些老年小鼠的筑巢能力。这原本是小鼠的一种本能,但会随着衰老而逐渐失去。在筑巢能力得到恢复后,即便是老年小鼠,也会用棉絮筑出自己喜欢在当中睡觉或育幼的巢。然而,如果是已被去除TIMP2的人类脐带血浆,则没有恢复老年小鼠学习和记忆能力的功效。与此相符,如果对通常在记忆测试中表现良好的年轻正常小鼠施用TIMP2中和抗体,其记忆能力也会显著减退。

    “TIMP2在大脑中的作用曾经被研究了一些,但我们对此所知的并不多,而且也不了解其在衰老中的作用,”文章第一作者Joseph Castellano博士说道:“在我们的研究中,TIMP2几乎完全复制出了我们用脐带血浆取得的记忆和学习能力提高效果,这似乎通过改善海马体的功能来实现的。”

    参考资料:

    [1] Human umbilical cord plasma proteins revitalize hippocampal function in aged mice

    [2] Protein in human umbilical cord blood rejuvenates old mice’s impaired learning, memory

    来源:学术经纬

    本周科研进展

    1. 日前,一个国际研究小组利用2013年至2016年间西非埃博拉疫情的病毒基因组数据库,揭示了加速或减缓疫情传播的因素,并呼吁使用实时测序和数据共享来控制今后病毒性疾病的爆发,该研究结果发表在《Nature》上。
    2. 英国诺丁汉大学流行病学家Stephen Weng和他的同事比较了ACC / AHA指南与随机森林,逻辑回归,梯度增强和神经网络这四种机器学习算法的应用 。所有四种技术都在没有人为指导的情况下通过分析大量数据形成了预测工具。他们证明,自我学习的计算机,相比较标准的医疗诊断程序而言,能够显著提高心脏病预测率。一旦投入使用,这一新的诊疗手段每年将拯救数以千计甚至百万计的生命。
    3. 中美研究人员在新一期美国《科学》杂志上报告说,他们研制出一种新型单细胞全基因组扩增技术,名为 LIANTI,跟以前技术相比,这项新技术在所有指标上都有大幅度提高,让单细胞扩增与测序更加精准。在此基础上不仅有望避免许多遗传性疾病遗传给后代,从基因组角度更深入地认识癌症也将成为可能。
    4. 一项最新遗传学研究使用了反向遗传学方法来探索基因功能,让研究人员得以评估人类基因功能丧失性突变的表型。研究发表在12日的英国《自然》杂志上,该成果标志着我们开始向大规模研究人类基因功能这一目标出发,并已为其奠定了基础。
    5. 在4月18日发表在《Nature Genetics》上的两项独立研究中,研究人员通过荟萃分析和全基因组关联研究发现了一些新的心房颤动风险变异,使这种变异的总数达二十多个。另外,这两项研究均表明SH3PXD2A附近的变异影响亚洲人的心房颤动风险,SH3PXD2A编码invadosome相关的支架蛋白,SH3PXD2A在人类心房和心室中表达,对神经鞘迁移很重要。
    6. 据《麻省理工技术评论》杂志网站17日报道,科学家们正在开发一种“CRISPR药丸”,其不会像抗生素药物对有益细菌和有害细菌进行“通杀”,而是超精准“杀灭”单种目标细菌。新研究为对付造成大规模致命感染的耐药性细菌,提供了一种全新方法。
    7. Broad研究所最新的一项研究表明,对病变组织进行RNA测序(RNA-seq),能发现可能导致孟德尔疾病的突变,例如致病性剪接位点变异,进而帮助临床对未确诊的遗传病患者进行诊断,而这些突变通过基因组测序则很难鉴定。这项研究于4月19日发表在《Science Translational Medicine 》上,是迄今为止最大的一项针对未确诊疾病患者进行转录组测序以确定遗传疾病相关未知突变的研究。
    8. MIT的研究人员利用合成生物标志物和纳米探针,开发出了一种比以往更加灵敏的检测方法来检测早期卵巢癌,他们的研究成果发表在了4月10日的《自然 生物医学工程》杂志上。新方法的进步性已经在小鼠体内得到了证实,它可以检查出直径小于2mm的肿瘤,换算到人体中,大约能够比现有的方法提前5个月检测到肿瘤!而且,研究人员介绍,除了卵巢癌,他们的方法也适用于其他癌症。
    9. 在两项针对小鼠的研究中,研究人员证实一种经设计抵抗导致脊髓小脑共济失调2型(SCA2)的基因突变的药物可能也被用来治疗肌萎缩性脊髓侧索硬化症(ALS)。这两项研究均于2017年4月12日在线发表在Nature期刊上。

      新发表文章

      【新技术】

      1. TRAPR: R Package for Statistical Analysis and Visualization of RNA-Seq Data.Lim JH et al.Genomics Inform. 2017 Mar

      2. A ChIP-Seq Data Analysis Pipeline Based on Bioconductor Packages.Park SJ et al.Genomics Inform. 2017 Mar

      3. CSReport: A New Computational Tool Designed for Automatic Analysis of Class Switch Recombination Junctions Sequenced by High-Throughput Sequencing.Boyer F et al.J Immunol. 2017 Apr 17.

      【动物】

      1. Identification and expression analysis of alternatively spliced new transcript isoform of Bax gene in mouse.Husain MA et al.Gene. 2017 Apr 12.

      2. Omics and cytokine discovery in fish: Presenting the yellowtail kingfish (Seriola lalandi) as a case study.Jacobson G et al.Dev Comp Immunol. 2017 Apr 14.

      3. Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens.Zhang X et al.Oncotarget. 2017 Mar 22.

      【植物】

      1. Fine-Mapping the Branching Habit Trait in Cultivated Peanut by Combining Bulked Segregant Analysis and High-Throughput Sequencing.Kayam G et al. Front Plant Sci. 2017 Apr 4

      【微生物】

      1. Mutations in Streptomycin Resistance Genes and Their Relationship to Streptomycin Resistance and Lineage of Mycobacterium tuberculosis Thai Isolates.Hlaing YM et al.Tuberc Respir Dis (Seoul). 2017 Apr

      2. Comparative Analysis of the Gut Microbial Communities in Forest and Alpine Musk Deer Using High-Throughput Sequencing.Hu X et al.Front Microbiol. 2017 Apr 3

      3. Elevated Air Humidity Changes Soil Bacterial Community Structure in the Silver Birch Stand.Truu M et al.Front Microbiol. 2017 Apr 3

      【肿瘤】

      1. RNA sequencing analyses reveal novel differentially expressed genes and pathways in pancreatic cancer.Mao Y et al.Oncotarget. 2017 Mar 22.

      2. Roles of long noncoding RNAs in colorectal cancer metastasis.Li H et al.Oncotarget. 2017 Mar 17.

      3. Genetic analysis of a morphologically heterogeneous ovarian endometrioid carcinoma.Geyer FC et al.Histopathology. 2017 Apr 18.

      4. Deep sequencing-based microRNA expression signatures in head and neck squamous cell carcinoma: dual strands of pre-miR-150 as antitumor miRNAs.Koshizuka K et al.Oncotarget. 2017 Mar 17.

      5. Robust In-Silico identification of cancer cell lines based on next generation sequencing.Otto R et al.Oncotarget. 2017 Mar 10.

      6. Identification and functional analysis of differentially expressed genes in poorly differentiated hepatocellular carcinoma using RNA-seq.Huang Y et al.Oncotarget. 2017 Mar 21.

      7. Identification of MAP kinase pathways as therapeutic targets in gallbladder carcinoma using targeted parallel sequencing.Li M et al.Oncotarget. 2017 Mar 31.

      【其他】

      1. Small non coding RNAs in adipocyte biology and obesity.Amri EZ et al.Mol Cell Endocrinol. 2017 Apr 12.

    该文章由WP-AutoPost插件自动采集发布

    原文地址:http://www.seq.cn/1241.html

    10800元!华西医院推出基于NGS的肿瘤易感基因遗传筛查项目

    10800元!华西医院推出基于NGS的肿瘤易感基因遗传筛查项目

    2017年5月10日,四川大学华西医院健康管理中心已正式开展肿瘤易感基因遗传筛查新项目,该项目可通过检测相关肿瘤易感基因,评估受检者的肿瘤遗传风险,可以做到针对性预防,该“肿瘤易感基因遗传筛查项目”基于二代测序平台,通过一次检测,全面分析涵盖多癌种《NCCN指南》和《医疗机构临床检验项目目录(2013年版)》等推荐的相关肿瘤易感基因,为肿瘤高风险人群提供专业、全面、精细化的肿瘤预防方案。

    据川大华西医院精准医学中心技术人员王婧介绍,肿瘤特别是恶性肿瘤的发生,主要是遗传因素和环境因素共同作用的结果。目前研究得知,在所有肿瘤中,有90%~95%的肿瘤是由复杂的基因、环境共同作用引发的,是“后天获得”的,而有5%~10%的是由遗传的变异基因引起的,也就是天生的。比如,结肠直肠癌、乳腺癌、卵巢癌和神经纤维瘤病等是遗传性肿瘤中相对发病率较高的。“如果父母的基因组中与遗传性肿瘤相关的基因存在致病变异,那么这些肿瘤致病变异就会遗传给子女,增加子女的患癌风险。”

    肿瘤易感基因遗传筛查就是给出受检者患癌风险评估。王婧表示,受检者需要静脉抽3~5毫升血,之后通过特定的仪器来进行检测。从抽血到最终结果出来需要30个工作日。目前,四川大学华西医院是川内首家推出肿瘤易感基因遗传筛查的公立医院,也是川内为数不多的几家使用二代测序技术的公立医院。二代测序技术比一代测序技术检测效率更高,同时,因一次性可检测多基因多样本,也降低了成本,减轻了受检者的经济负担。“目前可以查十多个癌种,一次性可检测106个肿瘤遗传易感基因做一次需要10800元。同时,这个检测针对的是天生的基因变异,理论上,是不会随着年龄增加而改变的,所以终生只需要检测一次够了。”

    2016年初,诺禾致源与四川大学华西医院联合建设精准医学中心,共同推进肿瘤精准治疗。双方希望将实验室打造成为肿瘤遗传风险评估、肿瘤用药检测、队列研究、大数据储存分析的研究平台,成为西南地区精准医学技术示范、研发和推广基地。诺禾医学检验所是诺禾致源下设的医学检测机构,其产品之一诺思安专业版,即是遗传性肿瘤基因筛查类产品,针对乳腺癌,结直肠癌,前列腺癌等 16 种遗传风险癌种,一次性分析 106 个遗传易感基因的外显子区域,精准指导高风险人群肿瘤预防,以期能够实现早发现,早诊断,早治疗。

    以上内容根据网络信息整理

    该文章由WP-AutoPost插件自动采集发布

    原文地址:http://www.seq.cn/1709.html